Metabolic Mechanisms of Drug Resistance in Leukemia

Mechanisms of drug resistance in human leukemia.

Drug resistance remains a major obstacle to cure of patients with acute leukemia. At the present time, most centers are reporting 90% complete remission rates in acute lymphatic leukemia (ALL) and 70%-80% complete remission rates in patients with acute nonlymphocytic leukemia (ANLL). However, 5-year disease-free survival rates are only 50% and 10%-15%, respectively, in these diseases. This is a...

Mechanisms of Drug Resistance

Progress of research into the problem of resistance to antibiotics is held back by lack of knowledge of the biochemical mechanisms by which these drugs act. Fortunately, it is possible to study some of the mechanisms of drug resistance, even at a biophysical or biochemical level, without necessarily knowing very much about how the drug works—just as it is possible to study (at least at a biolog...

Antifungal drug resistance of yeasts in dermatology: mechanisms, epidemiology and clinical impact

Superficial dermatophytoses are among the most common infectious disease. The most commonly used antifungal categories reazoles, polyenes and echinocandins. Due to the limited number of available antifungal drugs, toxicity and the emergence of resistant (intrinsic or acquired) strains, antifungal strategy needs to be developed. Recently the researchers try to find alternative antifungal agents....

Molecular mechanisms of drug resistance.

Mechanisms of cancer drug resistance.

The design of cancer chemotherapy has become increasingly sophisticated, yet there is no cancer treatment that is 100% effective against disseminated cancer. Resistance to treatment with anticancer drugs results from a variety of factors including individual variations in patients and somatic cell genetic differences in tumors, even those from the same tissue of origin. Frequently resistance is...